Coronavirus panic sent world share markets crashing again, compounding their worst week since the 2008 global financial crisis and bringing the wipeout to $5 trillion.

Hopes that the epidemic that started in China late last year would be over in months, and that economic activity would quickly return to normal, have been shattered as the number of international cases have spiraled.

“Investors are trying to price in the worst-case scenario and the biggest risk is what happens now in the United States and other major countries outside of Asia,” said SEI Investments Head of Asian Equities John Lau.

“These are highly uncertain times, no one really knows the answer and the markets are really panicking.”

Mainland China reported 327 new cases, the lowest since Jan. 23, taking its tally to more than 78,800 cases with almost 2,800 deaths.

But as the outbreak eases in China it is surging elsewhere.

Reuters reports that four more countries reported their first cases, taking the number of countries and territories outside China with infections to 55, with more than 4,200 cases killing about 70 people.

Countries other than China now account for about three-quarters of new infections.

An Italian man who arrived in Nigeria was confirmed as the first coronavirus case in Africa’s most populous country. And a person who returned on a flight from Iran became the first in New Zealand.

In eastern Europe, Belarus and Lithuania reported their first cases.

World Health Organization (WHO) Director General Tedros Adhanom Ghebreyesus said all nations should prepare.

“This virus has pandemic potential,” Tedros said in Geneva on Thursday. “This is not a time for fear. This is a time for taking action to prevent infection and save lives now.”

As of Friday, confirmed cases in Japan topped 200, with four deaths, excluding more than 700 cases and five more deaths from a quarantined cruise liner, Diamond Princess.

The hard-hit northern prefecture of Hokkaido declared a state of emergency and Tokyo Disneyland closed until March 15.

Prime Minister Shinzo Abe had called for schools to close and vowed to prevent a severe blow to an economy already teetering on the brink of recession.